UNC13B Polyclonal Antibody Reactivity Human
SKU: E-AB-52441-200
UNC13B Polyclonal Antibody Reactivity Human
| SKU # | E-AB-52441 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human UNC13B |
| Abbre | UNC13B |
| Synonyms | MGC133279, MGC133280, Munc13-2, Protein unc-13 homolog B, UN13B, UNC13, Unc13b, Unc13h2, hmunc13, munc13, unc-13 homolog B (C. elegans) |
| Swissprot | |
| Cellular Localization | Cytoplasm. Membrane. Cell membrane. Cell junction>synapse. Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding. |
| Concentration | 1.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Neuroscience, Signal transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:300 |
Background
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.