First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Tribioscience Vandetanib, VEGFRK Inhibitor (TBI2185)
Regular price
$ 87.95
Couldn't load pickup availability
Still have questions? Ask our experts!
Tribioscience Vandetanib, VEGFRK Inhibitor (TBI2185)
Research Use Only. Not intended for human use.
Buy Tribioscience products from MSE Supplies at the best value.
Product Details
Formal Name: 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-yl)methoxy]quinazoline
Alternate Names: ZD6474
Molecular Formula: C22H24BrFN4O2
Formula Weight: 475.40
CAS Number: 443913-73-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
Storage: -20°C
Stability: ≥ 2 years.
Applications
VEGFRK inhibitor
Functions
A potent and selective inhibitor of VEGFR2, (KDR IC50 = 40 nM). Also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC50 = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC50 = 500 nM) but shows selectivity against a panel of other tyrosine and serine-threonine kinases. Inhibits colony formation in seven cancer cell lines. Displays anti-angiogenesis activity.
Application Procedures