Product Details
Formal Name: 4,4,4-Trifluoro-1-(2-thienyl)-1,3-butanedione
Molecular Formula: C8H5F3O2S
Formula Weight: 222.18
CAS Number: 326-91-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Mitochondrial Complex II inhibitor
Functions
TTFA blocks the respiratory chain complex II causing inhibition of mitochondrial respiration. Respiratory chain complex II inhibition is caused via binding of TTFA to two ubiquinone binding sites, Qp and Qd. Inhibition of Complex II by TFA has been shown to cause a delay in overall cell cycle progression leading to oxidative stress. TTFA also was found to inhibit porcine liver carboxylesterase (IC50 = 0.54 µM).
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 1 month.