Tribioscience STF-62247, Autophagy Inducer (TBI1375)
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Tribioscience STF-62247, Autophagy Inducer (TBI1375)
Research Use Only. Not intended for human use.
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Product Details
Formal Name:Â N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
Molecular Formula:Â C15H13N3S
Formula Weight:Â 477.41
CAS Number:Â 315702-99-9
Purity:Â >98%
Formulation:Â powder
Solubility:Â Soluble in DMSO (up to 25 mg/ml).
Storage:Â RT
Stability: ≥ 2 years.
Applications
Autophagy inducer
Functions
Specifically induces autophagic cell death in VHL (von Hippel-Lindau)-deficient renal carcinoma cells both in vitro (IC50=625 nM) and in vivo. Renal cell carcinoma cell lines were radiosensitized by induction of autophagy following treatment with STF-62247. Cell permeable
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.