First dissolved in DMSO (up to at least 50 mg/ml) or in Ethanol (up to at least 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Tribioscience RIPA-56, RIP1 Inhibitor (More Potent Than 7-Cl-Nec1) (TBI4611)
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Tribioscience RIPA-56, RIP1 Inhibitor (More Potent Than 7-Cl-Nec1) (TBI4611)
Research Use Only. Not intended for human use.
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Product Details
Formal Name: N-Benzyl-N-hydroxy-2,2-dimethylbutanamide
Molecular Formula: C13H19NO2
Formula Weight: 221.30
CAS Number: 1956370-21-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 50 mg/ml) or in Ethanol (up to at least 50 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
RIP1 inhibitor (more potent than 7-Cl-Nec1)
Functions
RIPA-56 is a potent (IC50 = 13 nM, EC50 = 28nM for HT-29 cells) and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with significant metabolic stability (t1/2 = 128min human liver microsomal stability assay). RIPA-56 showed excellent kinase selectivity and did not inhibit IDO at 200 µM.
Application Procedures