First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Tribioscience Ranolazine, Selective Sodium Channel Blocker (TBI3701)
SKU: TBI3701-10MG
Tribioscience Ranolazine, Selective Sodium Channel Blocker (TBI3701)
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Product Details
Formal Name: (±)-N-(2,6-Dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)-propyl]piperazin-1-yl]acetamide
Molecular Formula: C24H33N3O4
Formula Weight: 427.54
CAS Number: 142387-99-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
Storage: RT
Stability: ≥ 1 year.
Applications
Selective sodium channel blocker
Functions
Ranolazine is an FDA-approved drug used for the treatment of chronic angina. It inhibits the late inward sodium current in heart muscle leading to decreased intracellular calcium levels. It blocks Nav 1.4, 1.5, 1.7 and 1.8 (IC50’s = 2.42, 6.22, 1.72(10.33), 21.53 µM respectively.
Application Procedures