Product Details
Formal Name: 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
Alternate Names: Diacylglycerol kinase inhibitor i
Molecular Formula: C27H26FN3OS
Formula Weight: 459.6
CAS Number: 93076-89-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
DAG kinase inhibitor
Functions
R-59022 is a diacylglycerol kinase (DAGK) inhibitor, nonselective for DAGK isotypes (IC50=2.8 µM in intact platelets). Induces autophagy and apoptosis in NG108-15 neuronal cells via an mTOR-independent mechanism. Prevents conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes. Blocks filovirus internalization in host cells.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.