First dissolved in water (up to at least 25 mg/ml) or in DMSO ( up to at least 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Tribioscience Quinacrine, Antiprotozoan; Anticancer (TBI4251)
SKU: TBI4251-20MG
Tribioscience Quinacrine, Antiprotozoan; Anticancer (TBI4251)
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Product Details
Formal Name: 6-Chloro-9-(4-diethylamino-1-methylbutyl)amino-2-methoxyacridine dihydrochloride
Molecular Formula: C23H30ClN3O·2HCl
Formula Weight: 472.88
CAS Number: 69-05-6
Purity: >98%
Formulation: powder
Solubility: Soluble in water (up to at least 25 mg/ml) or in DMSO ( up to at least 10 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Antiprotozoan; Anticancer
Functions
Quinacrine is an antiprotozoan drug used for malaria and giardiasis and has recently been investigated in treating lupus, as an anticancer agent, inflammation, and as a female sterilization agent. It has been found to have synergistic effects with vorinostat in the treatment of T-cell acute lymphoblastic leukemia via mitophagy blockage and an increase in ROS. Quinacrine displayed antitumor effects an intestinal cancer mouse model and HCT116 p53-/- xenografts via reduction in Chk1/2 expression and cell death induction in the G2-M phase. It promotes autophagic cell death in ovarian cancer cells via downregulation of p62/SQSTM1. Quinacrine is also an inhibitor of phospholipase A2.
Application Procedures