Product Details
Formal Name: Isolated from marine dionflagellates
Alternate Names: NSC 677083
Molecular Formula: C44H68O13
Formula Weight: 805.00
CAS Number: 78111-17-8
Purity: >98%
Formulation: Lyophilized
Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Protein phosphatase inhibitor
Functions
A naturally occurring polyether marine toxin. Potent and selective inhibitor of protein phosphatases inhibiting PP2A completely at 1 nM and PP1 at higher concentrations, while PP2C is not inhibited. It is an extremely useful tool for studying cellular protein phosphorylation. Induces apoptosis in a variety of cell types. Activates atypical protein kinase isotypes and induces insulin-like effects in adipocytes. Caution: SKIN IRRITANT, TUMOR PROMOTOR. Avoid contact.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.