Product Details
Formal Name: N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide
Molecular Formula: C21H22N2O4S
Formula Weight: 398.46
CAS Number: 309928-48-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml with warming).
Storage: RT
Stability: ≥ 2 years.
Applications
Cryptochrome (CRY) activator
Functions
A novel tool that specifically interacts with cryptochrome (CRY) preventing its ubiquitin-dependent degradation resulting in lengthening of the circadian period. KL-001-mediated CRY stabilization inhibits glucagon-induced gluconeogenesis in primary hepatocytes. Binds to the FAD-binding pocket of CRY2 as determined by co-crystal structure. Induces an increase in period along with simultaneous reduction in amplitude of circadian reporter expression in mammalian cells.
Application Procedures
First dissolved in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.