First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Tribioscience KB-R7943 Mesylate, TRPC Channel Blocker (TBI1163)
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Tribioscience KB-R7943 Mesylate, TRPC Channel Blocker (TBI1163)
Research Use Only. Not intended for human use.
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Product Details
Formal Name: 2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioures mesylate
Molecular Formula: C16H17N3O3S ∙ CH3SO3H
Formula Weight: 427.49
CAS Number: 182004-65-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
TRPC channel blocker
Functions
KB-R7943 is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50’s = 1.2-2.4 µM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts; 0.7µM in cultured rat forebrain). KB-R7943 has also been shown to inhibit the mitochondrial Ca2+ uniporter (MCU) – Ki = 5.5 µM. Recently shown to inhibit complex I in the mitochondrial respiratory chain (IC50 = 11.4 µM) and block NMDA receptors (IC50 = 13.4 µM).
Application Procedures