First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Tribioscience Formoterol Hemifumarate, β2-Adrenergic Agonist, Potent and Selective (TBI5092)
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Tribioscience Formoterol Hemifumarate, β2-Adrenergic Agonist, Potent and Selective (TBI5092)
Research Use Only. Not intended for human use.
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Product Details
Formal Name: (R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl] formamide
Alternate Names: BD 40A
Molecular Formula: C19H24N2O4 • ½C4H4O4
Formula Weight: 402.50
CAS Number: 43229-80-7
Purity: >99%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml)
Storage: RT
Stability: ≥ 2 years.
Applications
β2-adrenergic agonist, potent and selective
Functions
Potent, long-acting agonist specific to β2 (Ki = 7.6 nM), but not β1 (Ki > 2.6 µM), adrenergic receptors in trachea (pD2 = 9.3) over atrium (pD2 = 7.0). Reduces adhesion and superoxide anion production in cultured activated eosinophils. Reverses cachexia in rats and mice via inhibition of the ATP-ubiquitin-dependent proteolytic system. Rescues LPS-induced motor function deficits and nigrostriatal dopamine loss in a rat model of Parkinson’s. Clinically useful for respiratory diseases.
Application Procedures