First dissolved in DMSO (up to 8 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Tribioscience Flumazenil, GABAA Receptor Antagonist (TBI1081)
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Tribioscience Flumazenil, GABAA Receptor Antagonist (TBI1081)
Research Use Only. Not intended for human use.
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Product Details
Formal Name: 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester
Alternate Names: Ro 1722; Ro 15-1788
Molecular Formula: C15H14FN3O3
Formula Weight: 303.30
CAS Number: 78755-81-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 8 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
GABAA receptor antagonist
Functions
GABAA receptor, and benzodiazepine, antagonist (radioligand binding assay in rat cortical synaptosomes, IC50 = 2 nM. Panspecific for α1, α2, α3, or α5-containing GABAA receptors. When used at 10 µM in HEK-293 cells, flumazenil reduces α4β2δ GABAA receptor at the cell surface, likely through an increase in its endocytosis and lysosomal degradation. Used to study GABAA signaling, and develop new benzodiazepines. Reduces withdrawal sequelae in benzodiazepine dependence. Reverses the toxic effects, including coma and respiratory depression of zolpidem intoxication4 and gabapentin-induced coma.
Application Procedures