Product Details
Formal Name: 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine
Alternate Names: F-ara-A; NSC118218
Molecular Formula: C10H12FN5O4
Formula Weight: 285.2
CAS Number: 21679-14-1
Purity: >98%
Formulation: Powder
Solubility: Soluble in DMSO (up to 30 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
DNA synthesis inhibitor
Functions
A synthetic adenosine analog that inhibits DNA biosynthesis and is a clinically useful antineoplastic agent. In cells fludarabine accumulates as its 5’-triphosphate (F-ara-ATP) for which the rate-limiting step in formation is the conversion of fludarabine to its monophosphate. F-ara-ATP has multiple mechanisms of action including inhibition of ribonucleotide reductase, DNA polymerase, ligase and primase. A frequently used agent in myeloablative conditioning regimens for allogeneic hematopoietic cell transplantation. Immunosuppressive effects are mediated via inhibition of TNFα-stimulated production of IL-2 and IFN-γ through inactivation of NFκB. Antagonist at adenosine A1 receptors.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.