First dissolved in DMSO (up to 90 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Tribioscience Fenretinide (4-HPR), RAR Agonist; Dihydroceramide Desaturase Inhibitor (TBI2380)
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Tribioscience Fenretinide (4-HPR), RAR Agonist; Dihydroceramide Desaturase Inhibitor (TBI2380)
Research Use Only. Not intended for human use.
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Product Details
Formal Name: N-(4-Hydroxyphenyl)retinamide
Alternate Names: 4-HPR; MK-4016; Ro 22-4667
Molecular Formula: C26H33NO2
Formula Weight: 391.60
CAS Number: 65646-68-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 90 mg/ml) or in Ethanol (up to 25 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
RAR agonist; dihydroceramide desaturase inhibitor
Functions
Vitamin A (retinoic acid) analog that induces apoptosis in cancer cell lines via RAR-dependent and -independent mechanisms. Agonist for RARs, but with mixed response pattern, believed to be the reason for its low toxicity. Also inhibits dihydroceramide desaturase (IC50 = 2.3 µM), preventing obesity, hyperglycemia, insulin resistance and hepatic steatosis in mice. Inhibits Zika virus infection by interfering with the ZIKV NS5 / importin α/β1 heterodimer interaction and blocking nuclear import. Induces reactive oxygen species (ROS) production and NF-κB inhibition in FLT3-mutated AML cells.
Application Procedures