Tribioscience Etomoxir (+) Na, Carnitine Palmitoyltransferase Inhibitor (TBI4731)

Tribioscience Etomoxir (+) Na, Carnitine Palmitoyltransferase Inhibitor (TBI4731)

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Product Details

Formal Name: (R)-(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt

Molecular Formula: C₁₅H₁₈ClO₄·Na

Formula Weight: 320.74

CAS Number: 828934-41-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 5 mg/ml with warming)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Carnitine palmitoyltransferase Inhibitor

Functions

Etomoxir (828934-41-4) is an irreversible inhibitor of mitochondrial carnitine palmitoyl transferase 1 (CPT1). It is widely used to study fatty acid oxidation. Etomoxir has been investigated as a therapeutic agent for heart disease, diabetes, and cancer. Use of etomoxir in concentrations greater than 5 µM induces acute production of ROS with associated evidence of severe oxidative stress in proliferating T cells indicating a loss of specificity for CTP1 at these concentrations. 200 µM etomoxir inhibited complex I of the electron transport chain.

Application Procedures

First dissolved in DMSO (up to 5 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.