Tribioscience A77 1726, DHODH Inhibitor; Immunosuppresant (TBI1436)

Product Details

Formal Name: 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide

Alternate Names: Teriflunomide

Molecular Formula: C₁₂H₉F₃N₂O₂

Formula Weight: 270.21

CAS Number: 108605-62-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 5 mg/ml with warming).

Storage: -20°C

Stability: ≥ 2 years.

Applications

DHODH inhibitor; Immunosuppresant

Functions

A pyrimidine biosynthesis inhibitor and immunomodulator. Inhibits the mitochondrial dihydroorotate dehydrogenase (DHODH).  Leflunomide is rapidly metabolized in human hepatocytes to A77 1726.  Cell permeable.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml), or in Ethanol (up to 5 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.