Product Details
Formal Name: 1-(β-D-Ribofuranosyl)-5-fluorouracil
Alternate Names: FUrd
Molecular Formula: C9H11FN2O6
Formula Weight: 262.19
CAS Number: 316-46-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml) in Water (up to 50 mg/ml) or in Ethanol (up to 6 mg/ml with warming)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Proapoptotic antiproliferative agent
Functions
Inhibitor of ribozyme self-cleavage in mammalian cells. Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms besides global inhibition of RNA synthesis and processing contribute to 5-fluorouridine cytotoxicity. Cell permeable and active in vivo.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml) in Water (up to 50 mg/ml) or in Ethanol (up to 6 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO, water, or ethanol may be stored at -20°C for up to 3 months.