SERPINB4 Polyclonal Antibody Reactivity Human
SKU: E-AB-52213-200
SERPINB4 Polyclonal Antibody Reactivity Human
| SKU # | E-AB-52213 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human SERPINB4 |
| Abbre | SERPINB4 |
| Synonyms | Leupin, PI 11, PI-11, PI11, Peptidase inhibitor 11, Protease inhibitor (leucine serpin), SCCA 2, SCCA-2, SCCA1, SCCA2, SCCA2/SCCA1 fusion protein, Serine (or cysteine) proteinase inhibitor, Serpin B4, Serpin peptidase inhibitor, clade B (ov, clade B (ovalbumin), member 4 |
| Swissprot | |
| Cellular Localization | Cytoplasm. Seems to also be secreted in plasma by cancerous cells but at a low level. |
| Concentration | 0.72 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Cell Biology, Immunology |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:100 |
Background
The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. SERPINB4 (Serpin Family B Member 4) is a Protein Coding gene. Diseases associated with SERPINB4 include Squamous Cell Carcinoma and Chromosome 18Q Deletion Syndrome. Among its related pathways are Amoebiasis. GO annotations related to this gene include enzyme binding and protease binding. An important paralog of this gene is SERPINB3.