SAA1 Polyclonal Antibody Reactivity Human
SKU: E-AB-52681-200
SAA1 Polyclonal Antibody Reactivity Human
| SKU # | E-AB-52681 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human SAA1 |
| Abbre | SAA1 |
| Synonyms | Amyloid fibril protein AA, Amyloid protein A, MGC111216, PIG4, SAA, SAA2, Serum amyloid A protein, TP53I4, Tumor protein p53 inducible protein 4, amyloid A, serum, serum amyloid A-1 protein, serum amyloid A1 |
| Swissprot | |
| Cellular Localization | Secreted |
| Concentration | 1.2 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cardiovascular, Metabolism, Immunology, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:100-1:300 |
Background
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. SAA1 (Serum Amyloid A1) is a Protein Coding gene. Diseases associated with SAA1 include Amyloidosis Aa and Splenic Artery Aneurysm. Among its related pathways are Peptide ligand-binding receptors and Activated TLR4 signalling. GO annotations related to this gene include heparin binding and chemoattractant activity. An important paralog of this gene is SAA2.