Total Price: $0.00
Contact Information
Recombinant Rhesus macaque ICOS/AILIM/CD278 Protein (Fc Tag)
SKU: PKSQ050074-50
To better serve you, we would like to discuss your specific requirement.
Please Contact Us for a quote.
Recombinant Rhesus macaque ICOS/AILIM/CD278 Protein (Fc Tag)
| SKU # | PKSQ050074 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | AILIM, CD278, CVID1, ICOS, Inducible T-cell costimulator, activation-inducible lymphocyte immunomediatory molecule |
| Species | Rhesus macaque |
| Expression Host | HEK293 Cells |
| Sequence | Gly20-Lys140 |
| Accession | H9Z062 |
| Calculated Molecular Weight | 40.8 kDa |
| Observed Molecular Weight | 50-60 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Inducible T-cell costimulator, also known as activation-inducible lymphocyte immunomediatory molecule, CD278, AILIM, CVID1 and ICOS, belongs to the CD28 and CTLA4 cell surface receptor family.. ICOS contains one Ig-like V-type domain and exsits as a homodimer with disulfide-linked. ICOS is highly expressed on tonsillar T-cellsand can be induced by PMA and ionomycin, ICOS plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. Defects in ICOS are the cause of immunodeficiency common variable type 1, which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antige.