Recombinant Mouse TROP2/TACSTD2 Protein (His Tag)
SKU: PKSM041262-50
Recombinant Mouse TROP2/TACSTD2 Protein (His Tag)
| SKU # | PKSM041262 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | C80403, Cell surface glycoprotein Trop-2, EGP-1, GA733-1, Ly97, TROP-2, Tacstd2, Trop2, Tumor-associated calcium signal transducer 2 |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Gln25-Gly270 |
| Accession | Q8BGV3 |
| Calculated Molecular Weight | 28.8 kDa |
| Observed Molecular Weight | 38-55 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Tumor-associated calcium signal transducer 2(Tacstd2), also known as Cell surface glycoprotein Trop-2, belongs to the EPCAM family. Tacstd2 expressed in kidney, lung, ovary and testis and has high levels of expression in immortalized keratinocytes. Tacstd2 may functions as a growth factor receptor. It has negative regulation of branching involved in ureteric bud morphogenesis, cell motility, epithelial cell migration, ruffle assembly, stress fiber assembly and substrate adhesion-dependent cell spreading. Also, it has positive regulation of stem cell proliferation. Tacstd2 is capable of transducing an intracellular calcium signal and may play a role in tumor growth. It also has adhesive functions.