Recombinant Mouse TRAIL R2/TNFRSF10B Protein (Fc Tag)(Active)
SKU: PKSM041271-50
Recombinant Mouse TRAIL R2/TNFRSF10B Protein (Fc Tag)(Active)
| SKU # | PKSM041271 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD262, DR5, Death Receptor 5, KILLER, TNF-Related Apoptosis-Inducing Ligand Receptor 2, TNFRSF10B, TRAIL Receptor 2, TRAIL-R2, TRAILR2, TRICK2, Tumor Necrosis Factor Receptor Superfamily Member 10B, ZTNFR9 |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Asn53-Ser177 |
| Accession | Q9QZM4 |
| Calculated Molecular Weight | 40.9 kDa |
| Observed Molecular Weight | 50-75 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Mouse tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is a member of the TNFR family which contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10B exhibits high structural and functional homology to TRAIL-R1 (DR-4). TNFRSF10B is highly expressed in heart, lung, lymphocytes, spleen and kidney. In addition, it is regulated by the tumor suppressor p53. TNFRSF10B is the receptor for the cytotoxic ligand TNFSF10/TRAIL. It promotes the activation of NF-kappa-B and is essential for ER stress-induced apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis.