Recombinant Mouse TPBG/5T4 (C-6His)
SKU: PKSM041401-50
Recombinant Mouse TPBG/5T4 (C-6His)
| SKU # | PKSM041401 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | 5T4 Protein, 5T4AG Protein, Human, M6P1 Protein, WAIF1 Protein |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Ser32-Ser361 |
| Accession | Q9Z0L0 |
| Calculated Molecular Weight | 36.6 kDa |
| Observed Molecular Weight | 50-70 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
| Reconstitution | Not Applicable |
Background
Trophoblast glycoprotein, also known as TPBG and 5T4, it belongs to the LRR family of proteins. The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. TPBG may function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. It expressed by all types of trophoblasts as early as 9 weeks of development. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.