Recombinant Mouse SerpinA1/A1AT Protein (His Tag)
SKU: PKSM041362-50
Recombinant Mouse SerpinA1/A1AT Protein (His Tag)
| SKU # | PKSM041362 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Alpha-1 protease inhibitor 3, Alpha-1 protease inhibitor 6, Alpha-1-antitrypsin 1-3, Alpha-1-antitrypsin 1-6, Dom3, Dom6, Serine protease inhibitor 1-3, Serine protease inhibitor 1-6, Serine protease inhibitor A1c, Serpin A1c, Serpina1c, Spi1-3, Spi1-6 |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Glu25-Lys413 |
| Accession | AAH11040.1 |
| Calculated Molecular Weight | 44.3 kDa |
| Observed Molecular Weight | 50-60 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Alpha-1-antitrypsin 1-3(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. Mouse SERPIN A1 is a serine protease inhibitor whose targets include elastase,plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema orliver disease. Several transcript variants encoding the same protein have been found for this gene.