Recombinant Mouse PSGL-1/CD162 Protein (aa 42-307, Fc Tag)
SKU: PKSM041283-50
Recombinant Mouse PSGL-1/CD162 Protein (aa 42-307, Fc Tag)
| SKU # | PKSM041283 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD162, CLA, PSGL-1, PSGL1, Psgl-1, Psgl1, Selp1 |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Gln42-Cys307 |
| Accession | CAA62583.1 |
| Calculated Molecular Weight | 54.7 kDa |
| Observed Molecular Weight | 90 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
P-selectin glycoprotein ligand 1 is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. As cell adhesion molecules, multiple studies have shown that PSGL-1/ P-selectin interaction is required for the normal recruitment of leukocytes during inflammatory reactions, and also participates in hemostatic responses. PSGL-1 can also bind to other two members of the selectin family, E-selectin (endothelial) and L-selectin (leukocyte), but binds best to P-selectin.