Recombinant Mouse PDGFRa/CD140a Protein (Fc Tag)
SKU: PKSM041120-50
Recombinant Mouse PDGFRa/CD140a Protein (Fc Tag)
| SKU # | PKSM041120 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Alpha platelet-derived growth factor receptor, CD140 antigen-like family member A, CD140a, PDGF-R-alpha, PDGFR-alpha, PDGFRA, Platelet-derived growth factor alpha receptor, Platelet-derived growth factor receptor alpha |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Leu25-Glu524 |
| Accession | P26618 |
| Calculated Molecular Weight | 83.2 kDa |
| Observed Molecular Weight | 120-150 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Platelet-derived growth factor receptors (PDGFR) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. The PDGF family consists of PDGF-A, -B, -C and -D, which form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their monomeric forms. PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-α and -β. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -αα, -ββ and -αβ. PDGFRα and PDGFRβ are members of the class III RTK family. Inappropriate PDGFRα and PDGFRβ signaling has been linked to a number of proliferative disorders.