Recombinant Mouse LDHA/LDH1 Protein (His Tag)
SKU: PKSM041103-50
Recombinant Mouse LDHA/LDH1 Protein (His Tag)
| SKU # | PKSM041103 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | L-lactate dehydrogenase, LDHA, Ldh1 |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Met1-Phe332 |
| Accession | P06151 |
| Calculated Molecular Weight | 37.5 kDa |
| Observed Molecular Weight | 37 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 50%Glycerol, 500 mMNaCl, 5% Trehalose, 5% Mannitol, 0.01% Tween 80, 1mM EDTA, pH9.0. |
| Reconstitution | Not Applicable |
Background
Mouse Lactate dehydrogenase A (LDHA) is a member of the LDH/MDH superfamily and LDH family. LDHA catalyzes the inter-conversion of pyruvate and L-lactate with concomitant inter-conversion of NADH and NAD+. LDHA is found in most somatic tissues, though predominantly in muscle tissue and tumours. It has also been shown that LDHA plays an important role in the development, invasion and metastasis of malignancies. Mutations in LDHA have been linked to exertional myoglobinuria.