Recombinant Mouse CD48 Protein (His Tag)
SKU: PKSM041220-50
Recombinant Mouse CD48 Protein (His Tag)
| SKU # | PKSM041220 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | AI449234, AW610730, BCM1, BLAST-1, BLAST1, Bcm-1, CD48, MEM-102, SLAM Family Member 2, SLAMF2, Sgp-60 |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Phe23-Arg216 |
| Accession | Q18PH8 |
| Calculated Molecular Weight | 23.1 kDa |
| Observed Molecular Weight | 45-50 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
CD48 is a GPI-linked protein in the CD2 family of immunoglobulin superfamily proteins. CD48 is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. Among dendritic cells (DC), CD48 is selectively expressed on circulating myeloid DC and resident bone marrow and thymus DC. CD2, 2B4, and heparan sulfate function as CD48 ligands. CD48 is competent to transduce signals and can also trigger signaling through CD2 or 2B4. CD48 expressed on NK cells is coactivating, whereas CD48 expressed on other cell types inhibits NK cell activation.