Recombinant Human SLAM Family Member 6/SLAMF6/CD352/NTB-A (C-6His-Avi) Biotinylated
SKU: PKSH034021-100
Recombinant Human SLAM Family Member 6/SLAMF6/CD352/NTB-A (C-6His-Avi) Biotinylated
| SKU # | PKSH034021 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | UNQ, SLAM Family Member, SLAMF, SLAMF6, CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000, Activating NK Receptor, NK-T-B-Antigen, SLAM Family Member 6, UNQ6123, PRO20080, NTB-A, KAL1, Ly108 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gln22-Lys225 |
| Accession | Q96DU3 |
| Calculated Molecular Weight | 25.8 kDa |
| Observed Molecular Weight | 35-50 kDa |
| Tag | C-His-Avi |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
SLAM Family Member 6 (SLAMF6) is a 60 kD single-pass type I membrane protein that belongs to the SLAM subgroup of the CD2 family. Human SLAMF6/ NTB-A contains a 205 amino acid extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain, a 21 amino acid transmembrane segment and an 84 amino acid cytoplasmic domain, with two immunoreceptor tyrosine-based switch motifs. SLAMF6 is a homodimer. SLAMF6 can interact with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. Phosphorylation-dependent NTB-A association with SAP is required for full production of IFN-γ by NK cells and independent of EAT-2 binding. It Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. On B cells, NTB-A modulates immunoglobulin class switching and the balance between tolerance and autoimmunity.