Recombinant Human IL-16 (129 a.a.) protein(N-His)
SKU: PKSH034104-100
Recombinant Human IL-16 (129 a.a.) protein(N-His)
| SKU # | PKSH034104 |
| Expression Host | E.coli |
Description
| Synonyms | NIL, Interleukin, IL16, LCF, NIL16, PRIL16, prIL-16, IL-16, Interleukin-16, LCF (Lymphocyte Chemoattractant Factor), Lymphocyte chemoattractant factor, Pro-Interleukin-16 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1203-Ser 1332 |
| Accession | Q14005 |
| Calculated Molecular Weight | 14.1 kDa |
| Observed Molecular Weight | 18 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.1 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS,pH 8.0. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-16 (IL-16) is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4+ T cells. Human and murine IL-16 show significant cross-species reactivity.