Phospho-EEF2K (Ser366) Polyclonal Antibody
SKU: E-AB-21142-200
Phospho-EEF2K (Ser366) Polyclonal Antibody
| SKU # | E-AB-21142 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Applications | WB, IHC-p |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Applications | WB, IHC-p |
| Clonality | Polyclonal |
| Immunogen | Synthesized peptide derived from human eEF2K around the phosphorylation site of Ser366 |
| Synonyms | C86191, Calcium/calmodulin dependent eukaryotic elongation factor 2, Calcium/calmodulin dependent eukaryotic elongation factor 2 kinase, Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase, Calmodulin dependent protein kinase III, EC 2.7.1, cb365 |
| Swissprot | |
| Calculated MW | 82 kDa |
| Observed MW | 105 kDa |
| Cellular Localization | Cytosol, Other locations: cytoplasm, dendritic spine, postsynaptic density. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:100-1:300 |
Background
This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment.