PCBD1 Polyclonal Antibody Reactivity Human
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PCBD1 Polyclonal Antibody Reactivity Human
| SKU # | E-AB-53015 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human PCBD1 |
| Abbre | PCBD1 |
| Synonyms | 4 alpha hydroxy tetrahydropterin dehydratase, 4-alpha-hydroxy-tetrahydropterin dehydratase, 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of , 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) |
| Swissprot | |
| Calculated MW | 12 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Cytoplasm. Nucleus. Cytoplasmic and/or nuclear. |
| Concentration | 1.62 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:80-1:400 |
Background
This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants.