NR0B2 Polyclonal Antibody Reactivity Mouse
SKU: E-AB-52169-200
NR0B2 Polyclonal Antibody Reactivity Mouse
| SKU # | E-AB-52169 |
| Reactivity |
Human, Mouse, Rat |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human NR0B2 |
| Abbre | NR0B2 |
| Synonyms | group B, member 2a, NR0B2, Nr0b2a, Nuclear receptor subfamily 0, Nuclear receptor subfamily 0 group B member 2, Orphan nuclear receptor SHP, SHP, SHP-1, Shp1, Small heterodimer partner |
| Swissprot | |
| Cellular Localization | Nucleus. Cytoplasm. Colocalizes with NEUROD1 in the nucleus. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:30-1:150 |
Background
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain.The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors.The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation.In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function.Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.