Lamin B1 Polyclonal Antibody Host Rabbit
SKU: E-AB-40257-200
Lamin B1 Polyclonal Antibody Host Rabbit
| SKU # | E-AB-40257 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC, IF |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF |
| Clonality | Polyclonal |
| Immunogen | Recombinant Rat Lamin-B1 protein expressed by E.coli |
| Abbre | Lamin B1 |
| Synonyms | ADLD, LMN, LMN2, LMNB, LMNB1, Lamin-B1, Lmnb1, MGC111419, OTTHUMP00000159218, lamin B1 |
| Swissprot | |
| Calculated MW | 67 kDa |
| Observed MW | 72 kDa |
| Cellular Localization | Nucleus inner membrane. |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Cancer, Cell Biology, Signal Transduction, Tags and Cell Markers |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:250-1:500 |
| IHC | 1:200-1:600 |
Background
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).