HTRA2 Polyclonal Antibody Reactivity Mouse
SKU: E-AB-52111-200
HTRA2 Polyclonal Antibody Reactivity Mouse
| SKU # | E-AB-52111 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human HTRA2 |
| Abbre | HTRA2 |
| Synonyms | 2, E. coli, homolog of, HTRA 2, HTRA2, High temperature requirement protein A2, HtrA, HtrA like serine protease, HtrA serine peptidase 2, HtrA2, Omi stress regulated endoprotease, Omi stress-regulated endoprotease, P, PARK 13, PARK13, Protease serine 25, mitochondrial |
| Swissprot | |
| Calculated MW | 49 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Mitochondrion intermembrane space. Mitochondrion membrane. Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Cell Biology, Metabolism, Neuroscience |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
Background
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.