HSD11B1 Polyclonal Antibody Reactivity Human
SKU: E-AB-52192-200
HSD11B1 Polyclonal Antibody Reactivity Human
| SKU # | E-AB-52192 |
| Reactivity |
Human |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human HSD11B1 |
| Abbre | HSD11B1 |
| Synonyms | 11 DH, 11 beta HSD 1, 11 beta HSD1, 11 beta hydroxysteroid dehydrogenase 1, 11-DH, 11-beta hydroxysteroid dehydrogenase, 11-beta-HSD1, 11-beta-hydroxysteroid dehydrogenase 1, 11DH, Corticosteroid 11 beta dehydrogenase isozyme 1, Corticosteroid 11-beta-dehydr, type 1 |
| Swissprot | |
| Cellular Localization | Endoplasmic reticulum membrane. |
| Concentration | 1.2 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Metabolism, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:200 |
Background
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.