HIST1H2BA Polyclonal Antibody
SKU: E-AB-19784-200
HIST1H2BA Polyclonal Antibody
| SKU # | E-AB-19784 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human HIST1H2BA |
| Abbre | HIST1H2BA |
| Synonyms | (testis specific), H2B, H2B histone family, H2B histone family member U, H2B histone family member U testis specific, H2B testis, H2B1A, H2BFU, H2BT, H2ba, HIST1H2BA, Histone 1, Histone H2B, Histone H2B testi, Histone cluster 1 H2ba, bA317E16.3, member U, testis |
| Swissprot | |
| Calculated MW | 14 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Nucleus. Chromosome. |
| Concentration | 1.98 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:50-1:300 |
Background
The nucleosome, made up of four core histone proteins (H2A, H2B, H3, and H4), is the primary building block of chromatin. Originally thought to function as a static scaffold for DNA packaging, histones have now been shown to be dynamic proteins, undergoing multiple types of post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination , acetylation of specific lysine residues creates docking sites that facilitate recruitment of many transcription and chromatin regulatory proteins that contain a bromodomain, which binds to acetylated lysine residues . Histone H2B is rapidly phosphorylated at irradiation-induced DNA damage foci in mouse embryonic fibroblasts .