Glutamine Synthetase Polyclonal Antibody
SKU: E-AB-93350-200
Glutamine Synthetase Polyclonal Antibody
| SKU # | E-AB-93350 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IF |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF |
| Clonality | Polyclonal |
| Immunogen | Recombinant fusion protein of human Glutamine Synthetase |
| Abbre | Glutamine Synthetase |
| Synonyms | GLNS, GS, PIG43, PIG59, glutamine synthetase, GLUL |
| Swissprot | |
| Calculated MW | 42 kDa |
| Observed MW | 42 kDa
|
| Cellular Localization | Cytoplasm, Mitochondrion. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Neuroscience |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IF | 1:50-1:200 |
Background
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants.