FAS Polyclonal Antibody Reactivity Human
SKU: E-AB-40063-200
FAS Polyclonal Antibody Reactivity Human
| SKU # | E-AB-40063 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant human Tumor necrosis factor receptor superfamily member 6 protein |
| Abbre | FAS |
| Synonyms | ALPS 1A, ALPS1A, APO 1, APO 1 cell surface antigen, APO1, APO1 cell surface antigen, APT 1, APT1, Apo 1 antigen, Apo-1 antigen, Apo1 antigen, Apoptosis antigen 1, Apoptosis mediating surface antigen FAS, Apoptosis-mediating surface antigen FAS, CD 95, CD 95 antigen, CD95 |
| Swissprot | |
| Calculated MW | 37 kDa |
| Observed MW | 45 kDa |
| Cellular Localization | Secreted and Cell membrane. |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Cancer, Cell Biology, Immunology |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:1000 |
| IHC | 1:50-1:100 |
Background
Fas (CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. It can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells,or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form (40-55 kDa) of Fas is due to glycosylation.