DHCR24 Polyclonal Antibody Store at -20°C
SKU: E-AB-15380-200
DHCR24 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-15380 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human DHCR24 |
| Abbre | DHCR24 |
| Synonyms | 24 dehydrocholesterol reductase, 24-dehydrocholesterol reductase, 3 beta hydroxysterol delta 24 reductase, 3-beta-hydroxysterol delta-24-reductase, DCE, DHC24, Delta(24)-sterol reductase, Desmosterol to cholesterol enzyme, Dhcr24, Diminuto dwarf1 homolog, Diminuto/ |
| Swissprot | |
| Cellular Localization | Endoplasmic reticulum membrane. Golgi apparatus membrane. |
| Concentration | 0.7 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Cardiovascular, Metabolism, Neuroscience |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:30-1:150 |
Background
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.