CD74 Polyclonal Antibody
SKU: E-AB-40347-200
CD74 Polyclonal Antibody
| SKU # | E-AB-40347 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant Human HLA class II histocompatibility antigen gamma chain protein |
| Abbre | CD74 |
| Synonyms | CD 74, CD74, CD74 antigen, CD74 antigen (invariant polypeptide of major histocompatibility complex, CD74 molecule, CLIP, DHLAG, Gamma chain of class II antigens, class II antigen-associated), class II invariant chain, major histocompatibility complex |
| Swissprot | |
| Calculated MW | 33,26,18 kDa |
| Observed MW | 35 kDa |
| Cellular Localization | Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane. |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Cancer, Immunology |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:1000 |
| IHC | 1:100-1:300 |
Background
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.