CBX3 Monoclonal Antibody Store at -20°C
SKU: E-AB-22270-200
CBX3 Monoclonal Antibody Store at -20°C
| SKU # | E-AB-22270 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Applications | WB, IHC-p |
Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC-p |
| Clonality | Monoclonal |
| Immunogen | Recombinant Protein of HP-1γ |
| Abbre | CBX3 |
| Synonyms | CBX 3, CBX3, Chromobox homolog 3, Chromobox homolog 3 (HP1 gamma homolog, Chromobox protein homolog 3, Drosophila), GAMMA, HECH, HP1 gamma, HP1 gamma homo, Heterochromatin like protein 1, Heterochromatin protein 1 homolog gamma, Heterochromatin protein HP1 gamma |
| Swissprot | |
| Observed MW | 24 kDa |
| Cellular Localization | Nucleus. Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Clone No. | 4F4 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-2000 |
| IHC | 1:50-300 |
Background
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane.The protein encoded by this gene binds DNA and is a component of heterochromatin.This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane.The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane.This protein binds histone H3 tails methylated at Lys-9 sites.This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks.