CASP3 Monoclonal Antibody
SKU: E-AB-22209-200
CASP3 Monoclonal Antibody
| SKU # | E-AB-22209 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Applications | IHC-p |
Product Details
| Isotype | IgG |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC-p |
| Clonality | Monoclonal |
| Immunogen | Synthetic Peptide of Caspase-3 |
| Abbre | CASP3 |
| Synonyms | A830040C14Rik, Apopain, CASP-3, CASP3, CC3, CPP-32, CPP32, CPP32B, Casp3a, Caspase 3, Caspase-3 subunit p12, Cysteine p, apoptosis-related cysteine peptidase, apoptosis-related cysteine protease, apoptosis-related cysteine protease a |
| Swissprot | |
| Cellular Localization | Cytoplasm. |
| Tissue Specificity | Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Research Areas | Cancer, Cell Biology, Metabolism, Neuroscience |
| Clone No. | 4B8 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:100-200 |
Background
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.