ASAH2 Polyclonal Antibody Store at -20°C
SKU: E-AB-14747-200
ASAH2 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-14747 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human ASAH2 |
| Abbre | ASAH2 |
| Synonyms | AI585898, ASAH2, Acylsphingosine deacylase 2, BCDase, HNAC1, LCDase, MGC129777, N CDase, N acylsphingosine amidohydrolase (non lysosomal ceramidase) 2, N acylsphingosine amidohydrolase 2, N-CDase, N-acylsphingosine amidohydrolase 2, hCD, mitochondrial ceramidase |
| Swissprot | |
| Calculated MW | 86 kDa |
| Cellular Localization | Cell membrane. The neutral ceramidase soluble form is a secreted protein. According to PubMed:10781606, it is mitochondrial. However, they used a shorter form in its N-terminus, which may explain this localization which probably does not exist in vivo. |
| Concentration | 0.7 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Metabolism, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:200-1:1000 |
| IHC | 1:25-1:100 |
Background
Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger.