Tribioscience AZD1152-HQPA, Aurora B kinase Inhibitor (TBI4804)
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Tribioscience AZD1152-HQPA, Aurora B kinase Inhibitor (TBI4804)
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Product Details
Formal Name: 3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino-N-(3-fluorophenyl)-1H-pyrazole-5-acetamide
Alternate Names: Barasertib-HQPA; AZD2811
Molecular Formula: C26H30FN7O3
Formula Weight: 507.56
CAS Number: 722544-51-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 15 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Aurora B kinase inhibitor
Functions
AZD1152-HQPA is a potent and highly selective inhibitor of Aurora B. Aurora B Ki = 0.36 nM; Aurora A Ki = 1,369 nM. It inhibits the growth of tumors in multiple cancer models. Excessive ROS generation and upregulated tumor suppressor miRNAs have been proposed as a novel mechanisms of cytotoxicity of AZD1152-HQPA.
Application Procedures
First dissolved in DMSO (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.