Tribioscience Tunicamycin, ER Stress Inducer (TBI2111)

Tribioscience Tunicamycin, ER Stress Inducer (TBI2111)

Research Use Only. Not intended for human use.

Buy Tribioscience products from MSE Supplies at the best value. 

Product Details

Molecular Formula: C₃₈H₆₂N₄O₁₆ (tun. B)

Formula Weight: 830.9

CAS Number: 11089-65-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).

Storage: -20°C

Stability: ≥ 2 years.

Applications

ER stress inducer

Functions

Fermentation product from Streptomyces lysosuperificus. Provided as a mixture of tunicamycin A (C₁₄), B (C₁₅), C (C₁₆) and D (C₁₇) homologs varying in the number of carbon atoms in the fatty acid chain.

Potent inhibitor of GlcNAc phosphotransferase which thereby inhibits glycoprotein biosynthesis. Causes endoplasmic reticulum stress-induced autophagy and unfolded protein response. Arrests cell cycle in late G1.

Application Procedures

First dissolved in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.