Product Details
Formal Name: N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide
Molecular Formula: C17H12F9NO3S
Formula Weight: 481.30
CAS Number: 293754-55-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml) or in ethanol (up to 50 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
LXR agonist
Functions
Potent high affinity liver X receptor (LXRα and β) agonist, EC50~50 nM. Upregulates expression of ABCA1, a reverse cholesterol transporter, resulting in inhibition of cholesterol absorption. Inverse agonist at CAR. T0901317 was also shown to be an FXR agonist at lower potency than LXR thus appropriate controls must be employed when using this compound as a pharmacological tool. Decreases amyloid beta production in a mouse model of Alzheimer’s disease. Inhibits cellular senescence in endothelial cells.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml) or in ethanol (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.