Product Details
Formal Name: (R)-(-)-N-α-Dimethyl-N-2-propynylbenzeneethanamine, hydrochloride
Alternate Names: Selegiline
Molecular Formula: C13H17N • HCl
Formula Weight: 223.70
CAS Number: 14611-52-0
Purity: >98%
Formulation: powder
Solubility: Soluble in Water (up to 25 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
Neuroprotective agent
Functions
A potent inhibitor of monoamine oxidase B (MAO- B) which has been used for the treatment of Parkinson’s disease. Displays neuroprotective effects rescuing nigral dopaminergic neurons after systemic MPTP treatment. Rescues PC12 cells from trophic withdrawal-induced apoptosis. Glyceraldehyde-3-phosphate dehydrogenase has been found to be the putative target responsible for its neuroprotective effects.
Application Procedures
First dissolved in Water (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in Water may be stored at -20°C for up to 3 months.