Product Details
Formal Name: 4-Chloro-2-nitro-1-(phenylsulfonyl)-benzene
Alternate Names: NSC156750
Molecular Formula: C12H8ClNO4S
Formula Weight: 297.70
CAS Number: 86030-08-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml)
Storage: RT
Stability: ≥ 2 years.
Applications
Mitotic kinesin Kif18A inhibitor
Functions
A selective, ATP-competitive and reversible inhibitor of mitotic kinesin Kif18A, IC50=1.7 mM. Binds to an allosteric site near Kif18A loop 5 preventing a range of conformational changes thereby blocking motor function. Inhibits the differentiation of mouse bone marrow cells to dendritic cells. Suppresses the replication of influenza A virus, inhibiting activation of AKT, p38 MAPK, SAPK and RanBP3 leading to the prevention of nuclear export of viral ribonucleoprotein complexes. Greatly improves the viability of IAV-infected mice.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.